Dei Cas L, Manca C, Vasini G, Mansour M, Bernardini B, Visioli O
Arzneimittelforschung. 1980;30(3):498-500.
An investigation on the effect of diisobutyric ester of N-methyl-dopamine (SB 7505) on systolic time intervals (STI), heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure(DAP), saluretic activity was carried out on 8 male volunteer in-patients who had normal renal, gastrointestinal, cardiac and hepatic functions and were free from other serious illness. SB 7505 was administered orally at three doses of 50, 100 and 150 mg. HR, SAP and DAP either showed no variations or marginal insignificant shifts. STI decreased evidencing a dose-related positive inotropic effect like digitalis, but shorter than digitalis. SB 7505 also showed diuretic action with all three doses investigated. The positive inotropic effect and diuretic activity point to the possible usefulness of SB 7505 in treating some heart and kidney diseases.
对8名男性住院志愿者进行了一项关于N-甲基多巴胺二异丁酸酯（SB 7505）对收缩期时间间期（STI）、心率（HR）、收缩压（SAP）、舒张压（DAP）、利尿活性影响的研究。这些志愿者肾功能、胃肠功能、心脏功能和肝功能正常，且无其他严重疾病。以50、100和150毫克三种剂量口服给予SB 7505。心率、收缩压和舒张压要么没有变化，要么有微小的不显著变化。收缩期时间间期缩短，表明其具有类似洋地黄的剂量相关正性肌力作用，但比洋地黄作用时间短。在所研究的三种剂量下，SB 7505均显示出利尿作用。正性肌力作用和利尿活性表明SB 7505在治疗某些心脏和肾脏疾病方面可能有用。
