Juliano R L, Hsu M J, Peterson D, Regen S L, Singh A
Exp Cell Res. 1983 Jul;146(2):422-7. doi: 10.1016/0014-4827(83)90144-1.
We have examined the effects of liposomes on in vitro platelet aggregation. Liposomes were prepared from various conventional lipids and from a novel photopolymerizable phosphatidylcholine derivative (DPL, bis[1,2-(methacryloyloxy)dodecanoyl]-L-alpha-phosphatidylcholine). None of the liposome preparations studied caused marked platelet aggregation in either plasma or buffer solution. However, positively charged vesicles impaired the ability of platelets in plasma to aggregate in response to ADP, whereas negatively charged vesicles impaired the ability of platelets in buffer to aggregate in response to thrombin. DPL vesicles had only modest effects on platelets in plasma or buffer.
我们研究了脂质体对体外血小板聚集的影响。脂质体由各种传统脂质以及一种新型可光聚合的磷脂酰胆碱衍生物（DPL，双[1,2-(甲基丙烯酰氧基)十二烷酰基]-L-α-磷脂酰胆碱）制备而成。所研究的脂质体制剂在血浆或缓冲溶液中均未引起明显的血小板聚集。然而，带正电荷的囊泡会损害血浆中血小板对ADP作出反应而聚集的能力，而带负电荷的囊泡会损害缓冲液中血小板对凝血酶作出反应而聚集的能力。DPL囊泡对血浆或缓冲液中的血小板只有适度影响。
