Rajagopalan M, Gupta G, Sasisekharan V
FEBS Lett. 1983 Aug 8;159(1-2):285-9. doi: 10.1016/0014-5793(83)80465-7.
The Watson-Crick type of base pairing is considered to be mandatory for the formation of duplex DNA. However, conformational calculations carried out in our laboratory, have shown that some combinations of backbone torsion angles and sugar pucker lead to duplexes with Hoogsteen type of base pairing also. Here we present the results of energy calculations performed on A-T containing doublet sequences in the D-form with both Hoogsteen and Watson-Crick type of base pairing and the 3 viable models for the A-T containing polynucleotide duplex poly[d(A-T)].
沃森-克里克型碱基配对被认为是双链DNA形成所必需的。然而，我们实验室进行的构象计算表明，一些主链扭转角和糖环构象的组合也会导致形成具有 hoogsteen 型碱基配对的双链体。在这里，我们展示了对含有A-T的双链序列在D型中进行的能量计算结果，该双链序列具有hoogsteen型和沃森-克里克型碱基配对，以及含有A-T的多核苷酸双链体poly[d(A-T)]的3种可行模型。
