子宫异质性核糖核酸的特性及17β-雌二醇对其合成的影响。
Characterization of uterine heterogeneous nuclear ribonucleic acid and the effect of oestradiol-17 beta on its synthesis.
作者信息
Aziz S, Knowler J T
出版信息
Biochem J. 1978 Jun 15;172(3):587-93. doi: 10.1042/bj1720587.
Abstract
An early response to the administration of oestradiol-17 beta to immature rats is a dramatic stimulation in the synthesis of uterine hnRNA (heterogenous nuclear RNA). High-molecular-weight fractions of the hnRNA were purified and subfractionated on poly(U)-Sepharose into fractions that differed in their poly(A) content and their size profile on polyacrylamide gels. Oestrogen treatment of the rats stimulated the synthesis of all three fractions of high-molecular-weight hnRNA, but the kinetics of synthesis, degree of stimulation and size distribution of the newly synthesize RNA differed in each fraction.
摘要
给未成熟大鼠注射17β-雌二醇后的早期反应是子宫hnRNA（不均一核RNA）合成受到显著刺激。对hnRNA的高分子量部分进行纯化，并在聚（U）-琼脂糖上进行亚分级分离，得到在聚（A）含量和聚丙烯酰胺凝胶上的大小分布方面存在差异的级分。用雌激素处理大鼠刺激了所有三个高分子量hnRNA级分的合成，但新合成RNA的合成动力学、刺激程度和大小分布在每个级分中都有所不同。
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本文引用的文献
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The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis.用聚丙烯酰胺凝胶电泳法分离高分子量核糖核酸
Biochem J. 1967 Jan;102(1):251-7. doi: 10.1042/bj1020251.
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Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: possible evidence for a precursor relationship.海拉细胞异质性核RNA和快速标记的多核糖体RNA中的聚腺苷酸序列：前体关系的可能证据。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1336-40. doi: 10.1073/pnas.68.6.1336.
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A polynucleotide segment rich in adenylic acid in the rapidly-labeled polyribosomal RNA component of mouse sarcoma 180 ascites cells.在小鼠肉瘤180腹水细胞快速标记的多核糖体RNA组分中富含腺苷酸的多核苷酸片段。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1331-5. doi: 10.1073/pnas.68.6.1331.
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Possible involvement of nuclear DNA-like RNA in the control of ribosomal RNA synthesis.核DNA样RNA可能参与核糖体RNA合成的调控。
Biochim Biophys Acta. 1973 Jul 13;312(3):549-54. doi: 10.1016/0005-2787(73)90453-x.
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The oestrogen-stimulated synthesis of heterogeneous nuclear ribonucleic acid in the uterus of immature rats.雌激素刺激未成熟大鼠子宫中异质性核核糖核酸的合成。
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The role of protein in the estrogen-stimulated in vitro RNA synthesis of isolated rat uterine nucleoli.蛋白质在雌激素刺激的离体大鼠子宫核仁体外RNA合成中的作用。
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Evidence that all messenger RNA molecules (except histone messenger RNA) contain Poly (A) sequences and that the Poly(A) has a nuclear function.所有信使核糖核酸分子（组蛋白信使核糖核酸除外）均含有聚腺苷酸序列以及聚腺苷酸具有核功能的证据。
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