Evans A W, Johnson N W, Butcher R G
Histochem J. 1983 May;15(5):483-9. doi: 10.1007/BF01002702.
The levels of glucose-6-phosphate dehydrogenase activity have been assayed by quantitative histochemistry in normal, benign, potentially malignant and carcinomatous lesions of human oral mucosa. Dysplastic epithelium showed a higher activity of this enzyme than did morphologically normal, benign hyperplastic and neoplastic lesions and this may be an aid to early diagnosis. The increases in glucose-6-phosphate dehydrogenase activity in dysplastic human oral epithelium are sufficient to warrant a longitudinal study to evaluate further the significance of these changes in the process of malignant transformation.
已通过定量组织化学方法检测了人口腔黏膜正常、良性、潜在恶性和癌性病变中葡萄糖-6-磷酸脱氢酶的活性水平。发育异常的上皮组织中该酶的活性高于形态学正常、良性增生和肿瘤性病变，这可能有助于早期诊断。发育异常的人口腔上皮中葡萄糖-6-磷酸脱氢酶活性的增加足以开展一项纵向研究，以进一步评估这些变化在恶性转化过程中的意义。
