Johnson N W
Int Dent J. 1977 Mar;27(1):25-34.
Increasing attempts are now being made to measure and to assess the relative importance of histologic features in oral premalignant and malignant conditions in order to improve the accuracy of diagnosis and prognosis. Though certain individual features, such as DNA content of cell nuclei, or stereological parameters like nuclear : cytoplasmic ration or desmosome density can be very accurately quantified, no single feature can completely characterize the neoplastic process. Multifactorial studies are thus of great importance, even though it is not practicable to measure all the parameters included with the sam accuracy; in such studies retrospective computation of the relative importance of individual parameters is of greater value than arbitarily assigned weights. So far as early prediction of malignant transformation in oral premalignant lesions is concerned, great interest is now being shown in the reactivity of glucose-6-phosphate dehydrogenase in epithelial cells. For predicting the prognosis of patients with established squamous cell carcinoma of the mouth, it is now realized that thenature and intensity of the host immune inflammatory response seen in the connective tissue within the surrounding the tumour and in affected regional lymph nodes, is at least as important as are the features of the tumour cells themselves.
现在人们越来越多地尝试测量和评估组织学特征在口腔癌前病变和恶性病变中的相对重要性，以提高诊断和预后的准确性。尽管某些个体特征，如细胞核的DNA含量，或立体学参数，如核质比或桥粒密度，可以非常准确地量化，但没有单一特征能够完全表征肿瘤形成过程。因此，多因素研究非常重要，尽管以相同的精度测量所有参数并不实际；在此类研究中，对各个参数相对重要性的回顾性计算比任意分配权重更有价值。就口腔癌前病变恶性转化的早期预测而言，目前人们对上皮细胞中葡萄糖-6-磷酸脱氢酶的反应性非常感兴趣。对于预测已确诊的口腔鳞状细胞癌患者的预后，现在人们认识到，在肿瘤周围结缔组织和受影响区域淋巴结中看到的宿主免疫炎症反应的性质和强度，至少与肿瘤细胞本身的特征同样重要。
