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与普萘洛尔、普萘洛尔加肼屈嗪及二氮嗪相比，化合物AH 5158的一些血流动力学效应：AH 5158在高血压治疗中的应用

Some haemodynamic effects of compound AH 5158 compared with propranolol, propranolol plus hydrallazine, and diazoxide: the use of AH 5158 in the treatment of hypertension.

作者信息

Prichard B N, Thompson F O, Boakes A J, Joekes A M

出版信息

Clin Sci Mol Med Suppl. 1975 Jun;2:97s-100s. doi: 10.1042/cs048097s.

DOI:10.1042/cs048097s
PMID:802650
Abstract
  1. Intravenous administration of compound AH 5158, which possesses alpha- and beta-adrenergic receptor-blocking properties, produces haemodynamic effects similar to those seen from the combined effects of propranolol and hydrallazine. 2. Chronic oral administration has demonstrated that compound AH 5158 is an effective hypotensive agent capable of controlling the blood pressure in patients previously requiring large doses of drugs such as methyldopa. Some postural and exercise hypotension may be seen with larger doses.
摘要
  1. 静脉注射具有α和β肾上腺素能受体阻断特性的化合物AH 5158，会产生与普萘洛尔和肼屈嗪联合作用相似的血流动力学效应。2. 长期口服给药表明，化合物AH 5158是一种有效的降压药，能够控制先前需要大剂量服用甲基多巴等药物的患者的血压。大剂量使用时可能会出现一些体位性和运动性低血压。

相似文献

1
Some haemodynamic effects of compound AH 5158 compared with propranolol, propranolol plus hydrallazine, and diazoxide: the use of AH 5158 in the treatment of hypertension.与普萘洛尔、普萘洛尔加肼屈嗪及二氮嗪相比，化合物AH 5158的一些血流动力学效应：AH 5158在高血压治疗中的应用
Clin Sci Mol Med Suppl. 1975 Jun;2:97s-100s. doi: 10.1042/cs048097s.
2
Comparison of labetalol, hydrallazine, and propranolol in the therapy of moderate hypertension.拉贝洛尔、肼屈嗪和普萘洛尔治疗中度高血压的比较。
Med J Aust. 1980 Mar 8;1(5):224-5.
3
A controlled trial of labetalol (Trandate), propranolol and placebo in the management of mild to moderate hypertension.拉贝洛尔（柳胺苄心定）、普萘洛尔与安慰剂治疗轻至中度高血压的对照试验
Br J Clin Pharmacol. 1979 Jan;7(1):63-8. doi: 10.1111/j.1365-2125.1979.tb00898.x.
4
Combined alpha- and beta-receptor inhibition in the treatment of hypertension.联合α和β受体抑制治疗高血压。
Drugs. 1984;28 Suppl 2:51-68. doi: 10.2165/00003495-198400282-00005.
5
Combined alpha- and beta-adrenoreceptor blockade in hypertension: a controlled trial of labetalol (AH 5158) compared with propranolol and placebo.α和β肾上腺素能受体联合阻滞治疗高血压：拉贝洛尔（AH 5158）与普萘洛尔及安慰剂对比的对照试验
Clin Sci Mol Med Suppl. 1976 Dec;3:501s-503s. doi: 10.1042/cs051501s.
6
Labetalol compared with prindolol plus hydraliazine in the treatment of hypertension: a double-blind cross-over study.拉贝洛尔与吲哚洛尔加肼苯哒嗪治疗高血压的比较：一项双盲交叉研究。
Med J Aust. 1978 Jan 28;1(2):105-9.
7
Antihypertensive effect and plasma levels of labetalol. A comparison with propranolol and dihydrallazine.拉贝洛尔的降压作用及血浆水平。与普萘洛尔和双肼屈嗪的比较。
Int J Clin Pharmacol Biopharm. 1979 Feb;17(2):71-5.
8
Comparison of effects on cerebral blood flow of rapid reduction in systemic arterial pressure by diazoxide and labetalol in hypertensive patients: preliminary findings.二氮嗪和拉贝洛尔快速降低高血压患者体循环动脉压对脑血流量影响的比较：初步研究结果
Br J Clin Pharmacol. 1979;8(Suppl 2):195S-198S.
9
Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma.静脉注射AH 5158（异丁酰咪胺）与普萘洛尔治疗哮喘的比较。
Br Med J. 1975 Apr 12;2(5962):59-61. doi: 10.1136/bmj.2.5962.59.
10
Studies with prazosin--a new effective hypotensive agent. III. An acute double-blind cross-over study comparing the effects of single doses of prazosin and hydrallazine in combination with propranolol and a diuretic.关于新型有效降压药哌唑嗪的研究。III. 一项急性双盲交叉研究，比较单剂量哌唑嗪和肼屈嗪分别与普萘洛尔及一种利尿剂联合使用的效果。
Med J Aust. 1978 Jan 14;1(1):45-8.

引用本文的文献

1
Acute and long-term effects of labetalol on systemic and pulmonary haemodynamics in hypertensive patients.拉贝洛尔对高血压患者全身和肺血流动力学的急性及长期影响。
Eur J Clin Pharmacol. 1980 Jan;17(1):5-11. doi: 10.1007/BF00561670.
2
The electrophysiological effects of intravenous labetalol in man.静脉注射拉贝洛尔对人体的电生理效应。
Eur J Clin Pharmacol. 1981;20(4):241-4. doi: 10.1007/BF00618772.
3
The acute and chronic hypotensive effect of labetalol and the relationship with pretreatment plasma noradrenaline levels.拉贝洛尔的急性和慢性降压作用及其与治疗前血浆去甲肾上腺素水平的关系。
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):87S-92S. doi: 10.1111/j.1365-2125.1982.tb01894.x.
4
The use of labetalol in Japan: results of multicentre clinical trials.拉贝洛尔在日本的应用：多中心临床试验结果
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):49S-57S. doi: 10.1111/j.1365-2125.1982.tb01889.x.
5
Diazoxide and labetalol in acute hypertension during haemodialysis.血液透析期间急性高血压时使用二氮嗪和拉贝洛尔。
Eur J Clin Pharmacol. 1983;25(4):523-7. doi: 10.1007/BF00542122.
6
Pharmacokinetics, beta-adrenoceptor blockade and anti-hypertensive action of labetalol during chronic oral treatment.拉贝洛尔长期口服治疗期间的药代动力学、β-肾上腺素受体阻滞及降压作用
Br J Clin Pharmacol. 1980 Aug;10(2):121-6. doi: 10.1111/j.1365-2125.1980.tb01728.x.
7
Pharmacology of combined alpha-beta-blockade. II. Haemodynamic effects of labetalol.α-β受体联合阻滞的药理学。II. 拉贝洛尔的血流动力学效应。
Drugs. 1984;28 Suppl 2:35-50. doi: 10.2165/00003495-198400282-00004.
8
Comparison of labetalol with other anti-hypertensive drugs.拉贝洛尔与其他抗高血压药物的比较。
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):41S-47S. doi: 10.1111/j.1365-2125.1982.tb01888.x.
9
Improved deep controlled hypotension in aneurysmal surgery.动脉瘤手术中改良的深度控制性低血压
Acta Neurochir (Wien). 1982;60(3-4):201-14. doi: 10.1007/BF01406307.
10
Properties of labetalol, a combined alpha- and beta-blocking agent, relevant to the treatment of myocardial ischemia.拉贝洛尔（一种兼具α和β受体阻滞作用的药物）与心肌缺血治疗相关的特性。
Cardiovasc Drugs Ther. 1988 Sep;2(3):343-53. doi: 10.1007/BF00054642.