氯巴占——一种新型催眠药？
Clobazam--a new hypnotic?
作者信息
Kesson C M, Gray J M, Lawson D H
出版信息
Br J Clin Pharmacol. 1978 Sep;6(3):243-6. doi: 10.1111/j.1365-2125.1978.tb04592.x.
Abstract
1 A double-blind randomized trial to compare the relative efficacy of the 1,5-benzodiazepine, clobazam, the 1,4-benzodiazepine nitrazepam, and placebo as hypnotics was carried out. 2 A preference technique was used and the analyses were performed sequentially. 3. The results confirmed that nitrazepam was superior to placebo as a hypnotic but failed to show that clobazam was superior to either placebo or nitrazepam in a ratio of 2:1. Thus, it seems likely that the hypnotic properties of clobazam are minimal. 4 Clobazam is not suitable for use as a hypnotic in hospitalized patients.
摘要
- 开展了一项双盲随机试验，比较1,5 - 苯二氮䓬类药物氯巴占、1,4 - 苯二氮䓬类药物硝西泮与安慰剂作为催眠药的相对疗效。2. 使用了一种偏好技术，并依次进行分析。3. 结果证实，硝西泮作为催眠药优于安慰剂，但未能表明氯巴占在2:1的比例上优于安慰剂或硝西泮。因此，氯巴占的催眠特性似乎很微小。4. 氯巴占不适用于住院患者作为催眠药使用。
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引用本文的文献
1
Clobazam: a review of its pharmacological properties and therapeutic use in anxiety.氯巴占：其药理学特性及在焦虑症治疗中的应用综述
Drugs. 1980 Sep;20(3):161-78. doi: 10.2165/00003495-198020030-00001.
2
Clobazam: pharmacological and therapeutic profile.氯巴占：药理作用与治疗概况。
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):151S-155S. doi: 10.1111/j.1365-2125.1979.tb04685.x.
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Review of clinical studies on clobazam.氯巴占临床研究综述。
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):139S-150S. doi: 10.1111/j.1365-2125.1979.tb04684.x.
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