氯巴占临床研究综述。
Review of clinical studies on clobazam.
作者信息
Koeppen D
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):139S-150S. doi: 10.1111/j.1365-2125.1979.tb04684.x.
Abstract
1 Clobazam was compared with placebo and diazepam in 45 double-blind studies. 2 Clobazam dosage ranged from 5 mg daily (paediatric patients) to 120 mg daily (psychiatric in-patients). Usual daily dosage in out-patient therapy ranged from 20-30 mg clobazam. 3 Treatment duration varied from a few days up to 3.5 years. The usual duration of treatment was 2-4 weeks. 4 Clobazam was shown to be an efficacious and well tolerated anxiolytic agent in various neurotic and psychosomatic disorders. 5 Dosages showing distinct anxiolytic effects in out-patient therapy did not impair psychomotor performance.
摘要
- 在45项双盲研究中，对氯巴占与安慰剂和地西泮进行了比较。2. 氯巴占的剂量范围为每日5毫克（儿科患者）至每日120毫克（精神科住院患者）。门诊治疗的常用日剂量为氯巴占20 - 30毫克。3. 治疗持续时间从几天到3.5年不等。通常的治疗持续时间为2 - 4周。4. 氯巴占在各种神经症和心身疾病中被证明是一种有效且耐受性良好的抗焦虑药物。5. 在门诊治疗中显示出明显抗焦虑作用的剂量不会损害精神运动表现。
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