Ishiguro T, Yoshida Y, Tenzaki T, Matsumoto J
Nihon Sanka Fujinka Gakkai Zasshi. 1983 Jun;35(6):814-8.
A cytological screening program for the early detection of cervical cancer was started in the county of Santoh-Choh, north-eastern Shiga Prefecture in 1969. During the first four years between 1969 and 1972 all of the women aged more than 35 resident in this county took part in the screening program, and cervical cancer was found in 15 women out of a population of 2,960. The annual detection rate of 0.25% for the disease during this period was significantly higher than the average rate of 0.16% for the whole of Shiga Prefecture. Cervical cancer detection frequency in this county has subsequently been reduced over 7 years to about one third (0.09%) of the frequency before 1972. In this county, cervical cancer was found in three women who had received the annual repeat screenings more than three times. Re-evaluation of the previous smears in these patients revealed that two smears should have been diagnosed as positive. The present findings indicate that the effects of a mass-screening program may be improved by (1) the participation, at least once, in the screening program by all female residents, (2) annual repeat screening for more than three years and (3) adequate quality and/or accuracy control in the laboratory.
1969年，滋贺县东北部的桑托町启动了一项宫颈癌早期检测的细胞学筛查项目。1969年至1972年的头四年里，该町所有35岁以上的女性都参与了筛查项目，在2960人的筛查人群中，有15名女性被查出患有宫颈癌。这一时期该疾病的年检出率为0.25%，显著高于滋贺县整体0.16%的平均检出率。随后，该町的宫颈癌检出率在7年时间里降至1972年之前检出率的约三分之一（0.09%）。在该町，有三名接受过三次以上年度复查筛查的女性被查出患有宫颈癌。对这些患者之前涂片的重新评估显示，其中两份涂片本应被诊断为阳性。目前的研究结果表明，通过以下方式可以提高大规模筛查项目的效果：（1）所有女性居民至少参与一次筛查项目；（2）进行三年以上的年度复查筛查；（3）实验室进行充分的质量和/或准确性控制。
