Ishiguro T, Yoshida Y, Tenzaki T, Tanaka B
Nihon Sanka Fujinka Gakkai Zasshi. 1983 May;35(5):655-60.
During 1969 and 1979 cervical cancer was found in 269 women out of a population of 166,202 who were attending mass screening for cervical cancer in Shiga Prefecture, Japan. The overall 0.162% detection rate for this disease in the mass screening was within the range reported from other prefectures in Japan. The peak prevalence of carcinoma in situ was found at ages 40 to 44 years, while invasive cancer was found evenly distributed between ages 35 and 54 years. Among 269 women with cervical cancer, 68.8% were found to have suspicious or positive smears at the time of the initial screening, and 94% were detected by the time of the third screening. Ten women with carcinoma in situ had received the screenings almost annually more than three times and were found to have suspicious or positive smears at the time of the fourth or fifth screening. Re-evaluation of previous smears in these patients revealed that 55.6% should have been diagnosed as positive smears. Also eight women with cervical cancer in stage Ia or Ib were initially found to have positive smears at the time of the second screening, and re-evaluation of their previous smears showed that 50% had been suspicious or positive smears at the initial screening. These findings indicate that annual repeat screenings for at least three years are necessary for the early detection of cervical cancer. It is also emphasized that laboratory quality and/or accuracy should be properly controlled to avoid false negative results.
1969年至1979年期间，在日本滋贺县参加宫颈癌大规模筛查的166,202名女性中，有269名被发现患有宫颈癌。这种疾病在大规模筛查中的总体检出率为0.162%，处于日本其他县报告的范围内。原位癌的患病率高峰出现在40至44岁，而浸润癌在35至54岁之间分布均匀。在269名宫颈癌女性中，68.8%在初次筛查时涂片结果可疑或呈阳性，到第三次筛查时，94%的病例被检测出来。10名原位癌女性几乎每年接受三次以上筛查，在第四次或第五次筛查时涂片结果可疑或呈阳性。对这些患者之前涂片的重新评估显示，55.6%的涂片本应被诊断为阳性。此外，8名Ia期或Ib期宫颈癌女性最初在第二次筛查时涂片呈阳性，对她们之前涂片的重新评估显示，50%在初次筛查时涂片结果可疑或呈阳性。这些发现表明，为了早期发现宫颈癌，至少需要连续三年每年进行重复筛查。还强调应适当控制实验室质量和/或准确性，以避免假阴性结果。
