Feraudi M, Bert H
Arch Int Physiol Biochim. 1977 Feb;85(1):91-100. doi: 10.3109/13813457709069855.
14C-Distribution in the C3-chain of L-lactate after incubation of various 14-C-labelled prescursors ([1-14C] and [3-14C] glycerol; [3-14C] glyceraldehyde and glycerid acid; D- and L-[3-14C] serine; [1-14C] fructose and [6-14C] glucose) with homogenate showed that (1) most of the glycerol is metabolized to L-lactate via D-glyceraldehyde; the remainder may possibly form L-lactate via dihydroxyacetone; (2) a part of D-glyceraldehyde and D-glyceric acid may produce glycerol before L-lactate is formed; (3) D and L-serine do not form measurable amounts of L-lactate via D-glyceric acid; (4) rat-liver alcohol dehydrogenase (E.N.1.1.1.1) does not contribute to conversion to L-lactate of dihydroxyacetone phosphate from fructose nor of D-glyceraldehyde phosphate from glucose.
用各种14C标记的前体（[1-14C]和[3-14C]甘油；[3-14C]甘油醛和甘油酸；D-和L-[3-14C]丝氨酸；[1-14C]果糖和[6-14C]葡萄糖）与匀浆一起孵育后，14C在L-乳酸C3链中的分布表明：（1）大部分甘油通过D-甘油醛代谢为L-乳酸；其余部分可能通过二羟基丙酮形成L-乳酸；（2）一部分D-甘油醛和D-甘油酸在形成L-乳酸之前可能产生甘油；（3）D-和L-丝氨酸不会通过D-甘油酸形成可测量量的L-乳酸；（4）大鼠肝脏乙醇脱氢酶（E.N.1.1.1.1）对果糖的磷酸二羟基丙酮或葡萄糖的磷酸D-甘油醛转化为L-乳酸没有作用。
