Hicks P, Rolsten C, Brizzee D, Samorajski T
Neurobiol Aging. 1983 Spring;4(1):69-75. doi: 10.1016/0197-4580(83)90057-x.
We have measured several morphological parameters by electron microscopy of the frontal cortex (FC) and hippocampal CA1 (HC) capillaries in male Fischer 344 rats 3-, 9- and 24-months old. The results indicate that with increasing age there is an increase in the cross-sectional area of the basement membrane, increase in the fraction of endothelial cell and pericyte cytoplasmic area occupied by mitochondria in the FC, increase in the size of the pericyte mitochondria in both the FC and HC, increased capillary lumen area in the FC and decreased capillary lumen area in the HC. Also, the cytoplasmic area occupied by mitochondria in capillary pericytes is larger than in the endothelial cells of both FC and HC. These results suggest that there is regional variation in the age-associated changes in capillary morphometrics.
我们通过电子显微镜测量了3个月、9个月和24个月大的雄性Fischer 344大鼠额叶皮质（FC）和海马CA1区（HC）毛细血管的几个形态学参数。结果表明，随着年龄的增长，基底膜的横截面积增加，FC中内皮细胞和周细胞胞质区域中线粒体所占比例增加，FC和HC中周细胞线粒体的大小增加，FC中毛细血管腔面积增加，HC中毛细血管腔面积减小。此外，毛细血管周细胞中线粒体所占的胞质面积大于FC和HC的内皮细胞。这些结果表明，毛细血管形态测量的年龄相关变化存在区域差异。
