紫外线照射后哺乳动物细胞中的复制后修复：一种模型。
Postreplication repair in mammalian cells after ultraviolet irradiation: a model.
作者信息
Lavin M F
出版信息
Biophys J. 1978 Aug;23(2):247-56. doi: 10.1016/S0006-3495(78)85446-0.
Abstract
A model is presented for bypass of ultraviolet-induced damage in DNA during replication. The overall process is initiated by the introduction of a single-strand break into parental DNA near the point of arrest of synthesis, followed by a transient crossing-over step similar to that envisaged in genetic recombination. The mechanism proposed provides an alternative explanation to existing models and is entirely consistent with available data on postreplication repair in mammalian cells. In addition the model explains the low level of recombination repair observed in mammalian cells.
摘要
本文提出了一种在复制过程中绕过紫外线诱导的DNA损伤的模型。整个过程始于在合成停滞点附近的亲本DNA中引入一个单链断裂，随后是一个类似于基因重组中设想的瞬时交叉步骤。所提出的机制为现有模型提供了另一种解释，并且与哺乳动物细胞复制后修复的现有数据完全一致。此外，该模型解释了在哺乳动物细胞中观察到的低水平重组修复现象。
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本文引用的文献
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