通过在G2期或S期进行辐照增强紫外线照射的中国仓鼠细胞中的复制后修复。
Enhancement of postreplication repair in ultraviolet-light-irradiated Chinese hamster cells by irradiation in G2 or S-phase.
作者信息
D'Ambrosio S M, Aebersold P M, Setlow R B
出版信息
Biophys J. 1978 Jul;23(1):71-8. doi: 10.1016/S0006-3495(78)85433-2.
Abstract
Postreplication repair in synchronous Chinese hamster cells was determined after split doses of ultraviolet (UV) radiation. Repair was enhanced by irradiation of cells in G2 or S-phase with a small dose of UV radiation at least 1.5 h before a three-fold larger dose of UV. There was significantly greater enhancement when the first dose was given in G2 than when it was given in the S-phase 0.5-1.5 h before the test dose. These data indicate that enhancement of postreplication repair does not require active DNA replication and qualitatively is independent of when in the cell cycle the cells are irradiated.
摘要
在对同步化的中国仓鼠细胞进行分次紫外线（UV）照射后，测定了复制后修复情况。在给予三倍剂量的紫外线之前至少1.5小时，用小剂量紫外线照射处于G2期或S期的细胞，可增强修复。当第一次剂量在G2期给予时，比在测试剂量前0.5 - 1.5小时在S期给予时，增强效果显著更大。这些数据表明，复制后修复的增强并不需要活跃的DNA复制，并且在质量上与细胞在细胞周期的何时受到照射无关。
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