Isayama Y, Takahashi T
Ophthalmologica. 1983;187(1):8-18. doi: 10.1159/000309295.
The optic nerve and chiasm, obtained at autopsy, from 53 cases with clinical histories of cerebrovascular disturbances were histopathologically investigated, and ischemic changes in the posterior portion of the optic nerve were revealed in 12 cases. The progress of posterior ischemic optic neuropathy might be divided into necrotic, liquefactive and scar stages. The lesions were located in the transverse, peripheral, altitudinal and axial areas of the optic nerve. Occlusive changes of the vascular lumina due to atherosclerosis, arteriolosclerosis, capillosclerosis and emboli were demonstrated in association with the ischemic changes in the optic nerve parenchyma.
对53例有脑血管疾病临床病史且经尸检获得的视神经及视交叉进行了组织病理学研究，发现12例视神经后部存在缺血性改变。后部缺血性视神经病变的进展可分为坏死、液化和瘢痕阶段。病变位于视神经的横断、周边、高度和轴向区域。在视神经实质的缺血性改变中，发现了由动脉粥样硬化、小动脉硬化、毛细血管硬化和栓子引起的血管腔闭塞性改变。
