Gilmore I T, Eastwood J B, Ellis W R, Luck V A, Fenton S, O'Grady A J, Harris E, Murray-Lyon I M
Postgrad Med J. 1983 May;59(691):299-303. doi: 10.1136/pgmj.59.691.299.
Fifteen patients who had undergone a 14 inches X 4 inches jejuno-ileal bypass operation for obesity, 3 to 4 years earlier, were investigated by iliac bone biopsy, radiology and routine biochemistry, including 25-hydroxy-vitamin D and parathyroid hormone estimations. Two patients had histological osteomalacia which was mild in one. A further 9 patients had abnormal bone biopsies, there being an excess of trabecular bone surface covered by osteoid with a normal or reduced amount of calcification front. Six of these 9 showed an increase in trabecular resorption, although in none were there excessive numbers of osteoclasts. The likely explanation for these findings is that these 9 patients had early osteomalacia with mild hyperparathyroidism, making a total of 11 patients out of 15 with osteomalacia. Radiology and blood chemistry were poor predictors of histological bone disease.
对15名3至4年前因肥胖接受了14英寸×4英寸空肠回肠分流术的患者进行了髂骨活检、放射学检查和常规生化检查，包括25-羟维生素D和甲状旁腺激素测定。2名患者有组织学上的骨软化症，其中1名病情较轻。另有9名患者骨活检异常，类骨质覆盖的小梁骨表面过多，钙化前沿数量正常或减少。这9名患者中有6名小梁骨吸收增加，尽管均未出现破骨细胞数量过多的情况。这些发现的可能解释是，这9名患者患有早期骨软化症并伴有轻度甲状旁腺功能亢进，15名患者中共有11名患有骨软化症。放射学和血液生化检查对组织学骨病的预测效果不佳。
