Cooke R A, Nikles A, Roeser H P
Br J Pharmacol. 1978 Aug;63(4):677-81. doi: 10.1111/j.1476-5381.1978.tb17282.x.
1 The anti-fertility effects of cyclophosphamide, nitrogen mustard, vincristine and vinblastine were studied and compared in male rats. 2 The effects of the drugs on body weight and haematological values were used to monitor the pharmacological actions of the drugs. 3 All four drugs impaired fertility, the severity of the impairment depending on dose and duration of treatment. 4 Testicular size and histological appearances remained mostly normal, even in infertile animals, but seminiferous tubules were fewer in number and maturation arrest at the spermatid level was evident in some sections. 5 Recovery of drug-induced infertility occurred in 64% of treated animals, 9 to 40 weeks after cessation of treatment. 6 Morbidity and mortality were much higher with alkylating agents than with vinca alkaloids for approximately similar degrees of impairment in fertility.
研究并比较了环磷酰胺、氮芥、长春新碱和长春花碱对雄性大鼠的抗生育作用。
药物对体重和血液学指标的影响用于监测药物的药理作用。
所有四种药物均损害生育能力，损害的严重程度取决于剂量和治疗持续时间。
即使是不育动物，睾丸大小和组织学外观大多仍正常，但生精小管数量减少，在某些切片中可见精子细胞水平的成熟停滞。
64% 的治疗动物在停药 9 至 40 周后药物诱导的不育症得以恢复。
在生育能力受损程度大致相似的情况下，烷化剂导致的发病率和死亡率远高于长春花生物碱。
