Franchimont P, Gysen P, Lecomte-Yerna M J, Gaspar S
Rev Rhum Mal Osteoartic. 1983 Apr;50(4):249-53.
Radioactive sulphur (35SO4) is incorporated in the proteoglycans of chicken embryonic cartilage. In fact, the molecular weight of the macromolecules which bind the sulphur corresponds to monomeric proteoglycans and proteoglycan-hyaluronic acid complexes. This incorporation does not take place when the cartilage has been previously killed. The capture of 35S is stimulated by human serum, in a dose-dependent way. At doses less then, equal to and greater than the maximal plasma concentrations observed following a single oral dose (600 mg), acetyl salicylic acid and sodium salicylate inhibit the incorporation of radioactive sulphur in the cartilage. Under the same conditions, tiaprofenic acid and oxametacine have no effect on this metabolic parameter.
放射性硫（35SO4）被整合到鸡胚软骨的蛋白聚糖中。事实上，结合硫的大分子的分子量与单体蛋白聚糖和蛋白聚糖-透明质酸复合物相对应。当软骨预先被杀死时，这种整合就不会发生。人血清以剂量依赖的方式刺激35S的摄取。在单次口服剂量（600毫克）后观察到的最大血浆浓度以下、等于和高于该浓度时，乙酰水杨酸和水杨酸钠会抑制放射性硫在软骨中的整合。在相同条件下，噻洛芬酸和奥沙美辛对该代谢参数没有影响。
