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急性白血病诊断标准的可重复性研究。

A study of the reproducibility of the diagnostic criteria for acute leukaemia.

作者信息

Ost A, Lagerlöf B, Sundström C, Lindström P, Gyllenhammer H, Engstedt L, Skoog L

出版信息

Scand J Haematol. 1983 Sep;31(3):257-66. doi: 10.1111/j.1600-0609.1983.tb00650.x.

DOI:10.1111/j.1600-0609.1983.tb00650.x
PMID:6879109
Abstract

The Leukaemia Group of Middle Sweden recently started a new multicentre study of treatment of adult patients with acute leukaemia from 6 centres. The criteria for the diagnosis, subclassification, degree of leukaemic bone marrow infiltration, remission and relapse are to be used by the morphologists of 6 different pathology departments. The reproducibility of the criteria has been studied by 3 of the morphologists concerned, in a retrospective review of a strictly consecutive series of 79 adult patients treated at Södersjukhuset, Stockholm, Sweden, in the years 1978 to 1981. The results show that the reproducibility of the criteria and the concordance of the morphologists when using them increased when the criteria were made more detailed and precise.

摘要

瑞典中部白血病研究小组最近启动了一项新的多中心研究,该研究针对来自6个中心的成年急性白血病患者进行治疗。6个不同病理科的形态学家将使用诊断、亚分类、白血病骨髓浸润程度、缓解和复发的标准。其中3位相关形态学家对1978年至1981年期间在瑞典斯德哥尔摩南医院接受治疗的79例成年患者的严格连续系列病例进行了回顾性研究,以此来研究这些标准的可重复性。结果表明,当标准制定得更加详细和精确时,标准的可重复性以及形态学家使用这些标准时的一致性均有所提高。

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引用本文的文献

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Reproducibility of the morphological diagnostic criteria for acute myeloid leukemia: the GIMEMA group experience.
Ann Hematol. 1993 Apr;66(4):171-4. doi: 10.1007/BF01703231.
2
Prognostic significance of terminal transferase activity and glucocorticoid receptor levels in acute myeloid leukemia.末端转移酶活性和糖皮质激素受体水平在急性髓系白血病中的预后意义
Br J Cancer. 1984 Oct;50(4):443-9. doi: 10.1038/bjc.1984.199.