Müller P K, Raisch K, Matzen K, Gay S
Eur J Pediatr. 1977 Apr 26;125(1):29-37. doi: 10.1007/BF00470603.
Samples of bone from a patient with osteogenesis imperfecta were found to synthesize and contain type III collagen as well as type I collagen. Normal bone contains only type I collagen except in the lining cells of the bone marrow cavities. In the patient's tissue, type III collagen was localized in nonfibrillar structures in discrete areas of the bone. These and previous studies indicate that certain types of osteogenesis imperfecta may be caused by a failure of normal bone maturation and the sites in which the type III collagen is found appear to be defects in the bone.
从一名成骨不全患者身上获取的骨样本被发现既能合成并含有I型胶原蛋白，也能合成并含有III型胶原蛋白。正常骨仅含有I型胶原蛋白，骨髓腔的衬里细胞除外。在该患者的组织中，III型胶原蛋白定位于骨离散区域的非纤维结构中。这些研究以及之前的研究表明，某些类型的成骨不全可能是由正常骨成熟失败导致的，并且发现III型胶原蛋白的部位似乎是骨中的缺陷部位。
