Efron N, Carney L G
Am J Optom Physiol Opt. 1983 Jun;60(6):503-8. doi: 10.1097/00006324-198306000-00010.
Recent clinical and experimental evidence suggests that a better physiological response to hydrogel lens wear can be obtained with fenestrations. To determine whether those observations could be attributed to increased corneal oxygenation, the equivalent oxygen percentage (EOP) was measured at the cornea of eight subjects wearing hydrogel contact lenses which had multiple fenestrations of 0.8 and 1.8 mm. It was possible to increase the mean EOP by 1.7 +/- 1.3% O2 (p less than 0.002) beneath a standard thickness lens using four 1.8-mm fenestrations. However, such lenses were uncomfortable to wear. Fenestrations that provided comfortable wear (0.8-mm diameter) did not significantly increase the EOP beneath standard thickness lenses (-0.1 +/- 1.0% O2, p greater than 0.1 for four fenestrations, and +0.2 +/- 1.2% O2, p greater than 0.1 for eight fenestrations) or ultrathin lenses (-0.1 +/- 1.3% O2 p greater than 0.1 for four fenestrations). It is concluded that fenestrations do not provide a clinically efficient means of increasing the oxygen tension beneath hydrogel contact lenses.
最近的临床和实验证据表明，有开窗设计的水凝胶镜片能带来更好的生理反应。为了确定这些观察结果是否可归因于角膜氧合增加，对8名佩戴有多个0.8毫米和1.8毫米开窗的水凝胶隐形眼镜的受试者角膜处的等效氧百分比（EOP）进行了测量。使用四个1.8毫米的开窗，在标准厚度镜片下平均EOP可提高1.7±1.3% O2（p<0.002）。然而，这种镜片佩戴起来不舒服。佩戴舒适的开窗（直径0.8毫米）在标准厚度镜片下（四个开窗时为-0.1±1.0% O2，p>0.1；八个开窗时为+0.2±1.2% O2，p>0.1）或超薄镜片下（四个开窗时为-0.1±1.3% O2，p>0.1）均未显著提高EOP。得出的结论是，开窗并不是提高水凝胶隐形眼镜下氧张力的临床有效方法。
