López Alvarez-Buhilla P, Torres C, Valls A, Martín L, Alvarez J, Ruiz U
An Esp Pediatr. 1983 Apr;18(4):279-83.
Persistent localized interstitial emphysema (PLIE) is a severe complication of assisted ventilation in the neonatal period. From january 1980 to may 1982, 156 cases of IRDS where treated in our Intensive Care Unit. Three of these patients developed this type of emphysema. The initial management was conservative. In two cases, when high ventilatory pressures, and oxygen concentrations were needed to maintain normal blood gases, lobectomy was performed. In both of them mechanical ventilation could be withdrawn shortly after surgery. The third case was managed with conservative medical therapy, and the patient died. In conclusion, when PLIE is diagnosed and does not resolve with medical therapy, the patient needs increasingly higher oxygen concentrations and ventilatory pressures, or mechanical ventilation can not be withdrawn, lobectomy should be performed as long as the process is well localized.
持续性局限性间质性肺气肿（PLIE）是新生儿期辅助通气的一种严重并发症。1980年1月至1982年5月，我们的重症监护病房共治疗了156例呼吸窘迫综合征（IRDS）患者。其中3例发生了这种类型的肺气肿。初始治疗为保守治疗。2例患者在需要高通气压力和氧浓度来维持正常血气时，接受了肺叶切除术。术后不久，这2例患者均成功撤机。第3例患者采用保守药物治疗，最终死亡。总之，当诊断为PLIE且药物治疗无效，患者需要越来越高的氧浓度和通气压力，或无法撤机时，只要病变局限，应行肺叶切除术。
