Feichter G E, Goerttler K
Anal Quant Cytol. 1983 Jun;5(2):75-8.
Variations in nuclear areas in thyroid aspirates may be caused by many different pathologic conditions of the thyroid gland. Our experience in routine thyroid cytology has suggested that the age of the patient could also be a factor that can influence the nuclear size of thyroid epithelial cells. Planimetric measurements of nuclear areas of cytologically normal thyroid nuclei from patients with normal thyroid glands and from those with cold thyroid nodules, with each category containing two different age groups, revealed both a significant increase in nuclear areas in normal thyroid tissue from older patients and a significant increase in nuclear size variability among older patients with nodular goiters. This finding seems to indicate that patient age is another factor that exercises an influence upon the variability of nuclear areas, even in histologically normal thyroid glands.
甲状腺穿刺物中核面积的变化可能由甲状腺的许多不同病理状况引起。我们在常规甲状腺细胞学方面的经验表明，患者年龄也可能是影响甲状腺上皮细胞核大小的一个因素。对甲状腺正常患者以及甲状腺冷结节患者的细胞学正常甲状腺细胞核进行核面积的平面测量，每个类别包含两个不同年龄组，结果显示老年患者正常甲状腺组织的核面积显著增加，并且结节性甲状腺肿老年患者的核大小变异性也显著增加。这一发现似乎表明，即使在组织学正常的甲状腺中，患者年龄也是影响核面积变异性的另一个因素。
