Rouget J P, Goudemand J, Ducloux G, Dewailly P, Jaillard J
Ann Med Interne (Paris). 1983;134(2):111-6.
The authors report the presence of a circulating anticoagulant in two patients who had suffered multiple abortions. The circulating anticoagulant was discovered during evaluation of repeated phlebothromboses in the first case and of a chronic inflammatory syndrome in the second. While the apparently paradoxical relationship between the circulating anticoagulant and venous thrombosis is relatively well-known, that between the circulating anticoagulant and repetitive abortions is more difficult to establish. The rarely reported association of these three events leads us to a discussion of the nosologic place of this pathology and of the common ground it shares with S. L. E., as the circulating anticoagulant is of the antiprothrombinase variety, the antibody commonly called the lupus anticoagulant.
作者报告了两名多次流产患者体内存在循环抗凝物质。在对第一例反复发生的静脉血栓形成以及第二例慢性炎症综合征进行评估时发现了这种循环抗凝物质。虽然循环抗凝物质与静脉血栓形成之间明显矛盾的关系相对为人熟知，但循环抗凝物质与反复流产之间的关系则更难确定。这三种事件之间鲜有报道的关联促使我们讨论这种病理情况的疾病分类位置以及它与系统性红斑狼疮的共同之处，因为这种循环抗凝物质属于抗凝血酶原酶类型，这种抗体通常被称为狼疮抗凝物质。
