Eisenbrand G, Preussmann R, Schmähl D
Cancer Lett. 1978 Aug;5(2):103-6. doi: 10.1016/s0304-3835(78)80052-4.
N-nitrosoephedrine was administered orally to 32 male Srague--Dawley rats at doses of 120 mg/kg body wt. twice weekly. Of the treated animals, 50% died with preneoplastic and malignant lesions mainly in the liver, lung and forestomach. The median time of death of tumor bearing animals was 522 days after the beginning of the experiment. The observation of hyperkeratosis, papillomas, and 1 squamous cell carcinoma of the forestomach suggests that the compound not only exhibits systemic effects but is probably also a weak local carcinogen.
以120毫克/千克体重的剂量，每周两次给32只雄性斯普拉格-道利大鼠口服N-亚硝基麻黄碱。在接受治疗的动物中，50%死于主要发生在肝脏、肺和前胃的癌前病变和恶性病变。荷瘤动物的中位死亡时间是在实验开始后522天。前胃出现的角化过度、乳头状瘤和1例鳞状细胞癌表明，该化合物不仅具有全身作用，可能还是一种弱的局部致癌物。
