Garsik J T, Low W C, Whitehorn D
Brain Res. 1983 Jul 18;271(1):188-92. doi: 10.1016/0006-8993(83)91384-7.
The medical lemniscal evoked potential in response to a range of footshock intensities was recorded in spontaneously hypertensive (SHR) and Wistar Kyoto rats (WKY). Input-output (I-O) relationships were constructed as the percent of maximum response at each intensity. The SHR had a steeper I-O relationship than did the WKY. This difference was also evident when SHR maintained normotensive from weaning with hydralazine were compared with identically treated WKY. The treatment itself steepened the I-O relationship of the SHR while leaving that of the WKY unchanged. These results indicate an inherent hyperresponsiveness in the SHR dorsal column nuclei and an inhibitory effect of elevated blood pressure on transmission through these nuclei.
在自发性高血压大鼠（SHR）和Wistar Kyoto大鼠（WKY）中记录了对一系列足部电击强度作出反应的内侧丘系诱发电位。构建输入-输出（I-O）关系，以表示每种强度下最大反应的百分比。SHR的I-O关系比WKY更陡峭。当将用肼苯哒嗪从断奶起维持血压正常的SHR与接受相同处理的WKY进行比较时，这种差异也很明显。该处理本身使SHR的I-O关系变陡峭，而WKY的I-O关系保持不变。这些结果表明SHR背柱核存在内在的高反应性，以及血压升高对通过这些核的传导具有抑制作用。
