Dworkin B R, Elbert T, Rau H, Birbaumer N, Pauli P, Droste C, Brunia C H
Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey 17033.
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6329-33. doi: 10.1073/pnas.91.14.6329.
Activating the arterial baroreceptors blunts pain sensation and produces other forms of central nervous system inhibition in animals. These effects may be important to blood pressure regulation but have not been rigorously verified in humans. We describe (i) a noninvasive behaviorally unbiased method for baroreceptor stimulation and (ii) the application of this method to measurement of baroreceptor-mediated attenuation of pain perception and of the Achilles tendon reflex. The findings are relevant to basic mechanisms of blood pressure stabilization and cardiovascular reactivity and may also have implications for noncompliance with antihypertensive medications and for the pathophysiology of essential hypertension.
激活动脉压力感受器可减轻动物的疼痛感觉，并产生其他形式的中枢神经系统抑制。这些作用可能对血压调节很重要，但尚未在人体中得到严格验证。我们描述了（i）一种用于压力感受器刺激的非侵入性、行为无偏倚的方法，以及（ii）该方法在测量压力感受器介导的疼痛感知和跟腱反射衰减中的应用。这些发现与血压稳定和心血管反应性的基本机制相关，也可能对降压药物的不依从性和原发性高血压的病理生理学有影响。
