Grenier D, Mayrand D
Can J Microbiol. 1983 May;29(5):612-8.
The infectiousness of several combinations of bacteria containing Bacteroides gingivalis and other bacteria associated with periodontal diseases was evaluated by subcutaneous injection to guinea pigs. Among the seven mixtures studied, only one permitted the development of an infection easily transmissible to a second guinea pig; this bacterial mixture was composed of B. gingivalis, Fusobacterium nucleatum, Eubacterium saburreum, and Capnocytophaga ochracea (formerly Bacteroides ochraceus). Owing to its ability to synthesize many lytic enzymes and potentially cytotoxic products, B. gingivalis represented the most virulent species of the mixture. Results from in vitro studies suggest that the development of B. gingivalis in the infected animal depends on the growth of C. ochracea. Succinic acid produced in large amount by C. ochracea seems to be one of the growth factors used by B. gingivalis.
通过皮下注射到豚鼠体内，评估了几种含有牙龈拟杆菌和其他与牙周疾病相关细菌组合的传染性。在所研究的七种混合物中，只有一种能引发易于传播给第二只豚鼠的感染；这种细菌混合物由牙龈拟杆菌、具核梭杆菌、沙氏真杆菌和赭色二氧化碳嗜纤维菌（以前称为赭色拟杆菌）组成。由于牙龈拟杆菌能够合成多种裂解酶和潜在的细胞毒性产物，它是混合物中最具毒性的菌种。体外研究结果表明，牙龈拟杆菌在受感染动物体内的生长取决于赭色二氧化碳嗜纤维菌的生长。赭色二氧化碳嗜纤维菌大量产生的琥珀酸似乎是牙龈拟杆菌使用的生长因子之一。
