Sbordone L, Di Genio M, Bortolaia C
Facoltà di Medicina e Chirurgia Corso di Laurea in Odontoiatria e Protesi Dentaria, Cattedra di Parodontologia, Università degli Studi, Pisa.
Minerva Stomatol. 2000 Oct;49(10):485-500.
Strong relationships have been very often described between various form of periodontal disease (PD) and certain bacterial species, so that nowadays periodontal disease is recognized as an infectious disease. Destruction of periodontal supporting tissues happens as a response to very intricate host-parasite interactions. When the clinician will be able to fully understand and identify such phenomena it would be possible to succeed in a properly diagnosis and control of the active phase of periodontal disease. The first step in such a direction would be to analyze the common characteristic of some bacterial species, the so called suspected periodontopathogens. Such species namely Gram-negative, associated with the outbreak of periodontal disease have in common the capacity to disrupt the integrity of the host defences by means of the so called virulence factors. These factors may enhance the bacterial colonization or may interfere with the host response that ultimately results in periodontal support breakdown. The present review focuses on the virulence factors of the main suspected periodontopathogens evaluating the effects on the host immune response and directly on the periodontal tissues.
多种形式的牙周疾病（PD）与某些细菌种类之间常常被描述存在密切关系，因此如今牙周疾病被认为是一种感染性疾病。牙周支持组织的破坏是对非常复杂的宿主 - 寄生虫相互作用的一种反应。当临床医生能够充分理解和识别此类现象时，就有可能成功地对牙周疾病的活动期进行正确诊断和控制。朝着这个方向的第一步将是分析一些细菌种类的共同特征，即所谓的可疑牙周病原体。这类与牙周疾病爆发相关的革兰氏阴性菌具有通过所谓的毒力因子破坏宿主防御完整性的共同能力。这些因子可能增强细菌定植，或者干扰最终导致牙周支持组织破坏的宿主反应。本综述聚焦于主要可疑牙周病原体的毒力因子，评估其对宿主免疫反应以及直接对牙周组织的影响。
