Rotevatn S, Jodalen H G, Lie R K
Cardiovasc Res. 1983 May;17(5):290-3. doi: 10.1093/cvr/17.5.290.
The ultrastructure of the left ventricular wall was studied in mice given intraperitoneal injections of propranolol (5 mg or 20 mg.kg-1 b.w. twice a day for 48 h with an additional dose 3 h before death), and in saline injected controls. Injections of propranolol increase the number of lipid droplets in areas of the myocardium. Fractional volume of lipid droplets in myocardial cells determined using quantitative stereological techniques, showed an increase of 280% and 544% in the group receiving the lowest and highest doses respectively. Injections of propranolol were also followed by an increased granularity of the mitochondria.
对腹腔注射普萘洛尔（5毫克或20毫克/千克体重，每天两次，共48小时，在处死前3小时额外给药一次）的小鼠以及注射生理盐水的对照小鼠的左心室壁超微结构进行了研究。注射普萘洛尔会增加心肌区域脂质小滴的数量。使用定量体视学技术测定的心肌细胞中脂质小滴的分数体积显示，接受最低剂量和最高剂量的组分别增加了280%和544%。注射普萘洛尔后线粒体的颗粒度也增加。
