Smulow J B, Konstantinidis A, Sonnenschein C
Carcinogenesis. 1983 Sep;4(9):1085-8. doi: 10.1093/carcin/4.9.1085.
The development of a variety of odontogenic lesions was elicited by a single i.p. injection of N-nitroso-N-methylurea (NMU) at a dose of 150 mg/kg body weight. A total of 190 male Wistar/Furth rats were used in this study. The odontogenic lesions appeared macroscopically, mainly as supernumerary lower incisors, 88 +/- 3.48 (SE) days after administration of the carcinogen. Tumors were classified as compound and complex odontomas, odontoameloblastomas and ameloblastomas. 72% of rats (31 out of 43) 6 weeks old at the time of inoculation developed microscopic alterations in the odontogenic organs of the incisors; only 4% (2 of 49) of rats injected at 8 weeks of age developed similar alterations. These findings suggest the presence of an ontogenic mechanism susceptible to damage by chemical carcinogens.
通过腹腔注射一次剂量为150毫克/千克体重的N-亚硝基-N-甲基脲（NMU）诱发了多种牙源性病变。本研究共使用了190只雄性Wistar/Furth大鼠。牙源性病变在肉眼下出现，主要表现为额外的下切牙，在给予致癌物后88±3.48（标准误）天出现。肿瘤分为复合性和复杂性牙瘤、成釉细胞纤维瘤和成釉细胞瘤。接种时6周龄的大鼠中有72%（43只中的31只）在切牙的牙源性器官中出现了微观改变；8周龄注射的大鼠中只有4%（49只中的2只）出现了类似改变。这些发现表明存在一种易受化学致癌物损伤的个体发生机制。
