Reichart P A, Althoff J
Exp Pathol (Jena). 1980;18(5):288-96. doi: 10.1016/s0014-4908(80)80034-2.
Wistar rats given a single intraperitoneal injection of 75 mg cyclophosphamide revealed dental anomalies in the form of shortening or lengthening of incisors, and development of supernumerary teeth. Rats given additionally 5 mg/kg b. w. of a nitrosomethylurea solution over a period of four months showed the same dental anomalies, but with relatively shorter latency times. In a supplementary investigation examining the effects of benzo(a)pyrene and nitrosomethylurea applied locally to the organon dentale, neoplastic lesions and dental dysplasia were seen.
给Wistar大鼠腹腔注射一次75毫克环磷酰胺后，出现了门牙缩短或延长以及多生牙形成等牙齿异常情况。另外，连续四个月给大鼠注射5毫克/千克体重的亚硝基甲基脲溶液，也出现了相同的牙齿异常，但潜伏期相对较短。在一项补充研究中，对局部应用于牙器官的苯并(a)芘和亚硝基甲基脲的影响进行了检查，发现了肿瘤性病变和牙齿发育异常。
