年龄对大鼠经3,2'-二甲基-4-氨基联苯诱导的多器官致癌作用的影响，尤其涉及前列腺。
Effects of age on multiple organ carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl in rats, with particular reference to the prostate.
作者信息
Shirai T, Nakamura A, Fukushima S, Takahashi S, Ogawa K, Ito N
机构信息
First Department of Pathology, Nagoya City University Medical School.
出版信息
Jpn J Cancer Res. 1989 Apr;80(4):312-6. doi: 10.1111/j.1349-7006.1989.tb02312.x.
Abstract
The effects of age on multi-organ carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl (DMAB) in male F344 rats were examined. Groups of 5-, 35-, and 65-week-old animals were given 4 weekly sc injections of DMAB at a dose of 200 or 150 mg/kg body weight. Prostate carcinomas were induced in 8 to 19% of rats treated, no significant differences in the incidence between different ages being observed. Tumors in the small intestine, skin, pancreas and peritoneum, however, developed more frequently in young than in old animals, whereas higher incidences of testis, preputial and mammary gland lesions were found in the 35- and/or 65-week-old groups. Colon and Zymbal gland carcinogenesis did not reveal any age dependence.
摘要
研究了年龄对雄性F344大鼠由3,2'-二甲基-4-氨基联苯（DMAB）诱导的多器官致癌作用的影响。将5周龄、35周龄和65周龄的动物分组，每周皮下注射4次DMAB，剂量为200或150mg/kg体重。接受治疗的大鼠中有8%至19%诱发了前列腺癌，未观察到不同年龄组之间的发病率有显著差异。然而，小肠、皮肤、胰腺和腹膜中的肿瘤在年轻动物中比在老年动物中更频繁地发生，而在35周龄和/或65周龄组中发现睾丸、包皮和乳腺病变的发生率更高。结肠和齐默尔氏腺的致癌作用未显示出任何年龄依赖性。
相似文献
1
Effects of age on multiple organ carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl in rats, with particular reference to the prostate.年龄对大鼠经3,2'-二甲基-4-氨基联苯诱导的多器官致癌作用的影响，尤其涉及前列腺。
Jpn J Cancer Res. 1989 Apr;80(4):312-6. doi: 10.1111/j.1349-7006.1989.tb02312.x.
2
Modification by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) of 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced rat pancreatic and intestinal tumorigenesis.2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（PhIP）对3,2'-二甲基-4-氨基联苯（DMAB）诱导的大鼠胰腺和肠道肿瘤发生的影响
Cancer Lett. 1998 Feb 13;124(1):31-7. doi: 10.1016/s0304-3835(97)00441-2.
3
4
Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl.用腹腔注射N-羟基-3,2'-二甲基-4-氨基联苯处理的F344大鼠中前列腺癌的选择性诱导。
Jpn J Cancer Res. 1990 Apr;81(4):320-3. doi: 10.1111/j.1349-7006.1990.tb02569.x.
5
Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl.牛油，而非紫苏油或玉米油，可促进3,2'-二甲基-4-氨基联苯诱导的大鼠前列腺癌和肠道癌发生。
Jpn J Cancer Res. 2001 Oct;92(10):1026-33. doi: 10.1111/j.1349-7006.2001.tb01056.x.
6
Enhancing effect of cadmium on rat ventral prostate carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl.镉对3,2'-二甲基-4-氨基联苯诱导的大鼠腹侧前列腺癌发生的增强作用。
Jpn J Cancer Res. 1993 Oct;84(10):1023-30. doi: 10.1111/j.1349-7006.1993.tb02796.x.
7
Lack of modification by naturally occurring antioxidants of 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis.天然抗氧化剂对3,2'-二甲基-4-氨基联苯引发的大鼠前列腺癌发生缺乏修饰作用。
Cancer Lett. 1991 Jul 4;58(3):241-6. doi: 10.1016/0304-3835(91)90107-s.
8
Different carcinogenic responses in a variety of organs, including the prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl.给五种不同品系的大鼠投喂3,2'-二甲基-4-氨基联苯后，在包括前列腺在内的多种器官中出现的不同致癌反应。
Carcinogenesis. 1990 May;11(5):793-7. doi: 10.1093/carcin/11.5.793.
9
10
Lack of modifying effects of 4-n-octylphenol on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats.4-正辛基苯酚对3,2'-二甲基-4-氨基联苯诱导的大鼠前列腺癌发生缺乏修饰作用。
Ecotoxicol Environ Saf. 2002 Mar;51(3):210-5. doi: 10.1006/eesa.2002.2132.
引用本文的文献
1
Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl.牛油，而非紫苏油或玉米油，可促进3,2'-二甲基-4-氨基联苯诱导的大鼠前列腺癌和肠道癌发生。
Jpn J Cancer Res. 2001 Oct;92(10):1026-33. doi: 10.1111/j.1349-7006.2001.tb01056.x.
2
Children's health, susceptibility, and regulatory approaches to reducing risks from chemical carcinogens.儿童健康、易感性以及降低化学致癌物风险的监管方法。
Environ Health Perspect. 2001 Feb;109(2):187-92. doi: 10.1289/ehp.01109187.
3
Influence of aging on multi-organ carcinogenesis in rats induced by N-methyl-N-nitrosourea.衰老对N-甲基-N-亚硝基脲诱导的大鼠多器官致癌作用的影响。
Jpn J Cancer Res. 1993 Feb;84(2):139-46. doi: 10.1111/j.1349-7006.1993.tb02847.x.
4
Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats.在大鼠经N-甲基-N-亚硝基脲初始处理后，增强6种不同致癌物对多器官肿瘤发生的影响。
Jpn J Cancer Res. 1991 Dec;82(12):1397-405. doi: 10.1111/j.1349-7006.1991.tb01812.x.
5
Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl.用腹腔注射N-羟基-3,2'-二甲基-4-氨基联苯处理的F344大鼠中前列腺癌的选择性诱导。
Jpn J Cancer Res. 1990 Apr;81(4):320-3. doi: 10.1111/j.1349-7006.1990.tb02569.x.
6
Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model.多种化学物质对大鼠广谱器官致癌模型中肿瘤发生的修饰作用。
Jpn J Cancer Res. 1992 Aug;83(8):812-20. doi: 10.1111/j.1349-7006.1992.tb01985.x.
本文引用的文献
1
EXPERIMENTALLY-INDUCED NEOPLASMS IN THE SKIN OF MICE. II. THE INFLUENCE OF AGE ON TUMOR INDUCTION IN RHINO MICE.
J Invest Dermatol. 1965 Jun;44:399-407. doi: 10.1038/jid.1965.73.
2
Induction of pancreatic DNA damage and nodules in rats treated with N-nitrosobis(2-oxopropyl)amine and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine.用N-亚硝基双（2-氧代丙基）胺和N-亚硝基（2-羟丙基）（2-氧代丙基）胺处理的大鼠胰腺DNA损伤和结节的诱导。
Carcinogenesis. 1982;3(6):715-7. doi: 10.1093/carcin/3.6.715.
3
4
Modifying effect of aging on chemical carcinogenesis. A review.
Mech Ageing Dev. 1981 Apr;15(4):399-414. doi: 10.1016/0047-6374(81)90044-0.
5
Spontaneous tumors in F-344/DuCrj rats.F-344/DuCrj大鼠的自发性肿瘤。
Gan. 1983 Jun;74(3):365-72.
6
Age-dependent odontogenic lesions in rats after a single i.p. injection of N-nitroso-N-methylurea.单次腹腔注射N-亚硝基-N-甲基脲后大鼠的年龄依赖性牙源性病变
Carcinogenesis. 1983 Sep;4(9):1085-8. doi: 10.1093/carcin/4.9.1085.
7
Progression of rat mammary development with age and its relationship to carcinogenesis by a chemical carcinogen.大鼠乳腺随年龄的发育进程及其与化学致癌物致癌作用的关系。
Int J Cancer. 1983 Mar 15;31(3):321-7. doi: 10.1002/ijc.2910310312.
8
Review: prostate cancer epidemiology.综述：前列腺癌流行病学
Prostate. 1984;5(6):621-9. doi: 10.1002/pros.2990050608.
9
Adenocarcinomas of the prostate induced by N-nitroso-N-methylurea in rats pretreated with cyproterone acetate and testosterone.在经醋酸环丙孕酮和睾酮预处理的大鼠中，由N-亚硝基-N-甲基脲诱导的前列腺腺癌。
Cancer Lett. 1983 Feb;18(1):69-78. doi: 10.1016/0304-3835(83)90119-2.
10
Differentiation of the mammary gland and susceptibility to carcinogenesis.乳腺的分化与致癌易感性。
Breast Cancer Res Treat. 1982;2(1):5-73. doi: 10.1007/BF01805718.
Zotero 插件