El-Nahas A M, Paraskevakou H, Zoob S, Rees A J, Evans D J
Clin Sci (Lond). 1983 Oct;65(4):399-406. doi: 10.1042/cs0650399.
We have examined the effect of a low protein diet on the development of glomerular sclerosis and progressive renal failure after subtotal nephrectomies in rats. Two groups of male Sprague-Dawley rats were studied after five-sixths nephrectomy; group 1 were maintained on a normal diet (13.5 g day-1 kg-1 body weight) and group 2 were fed with a low protein diet (6 g day-1 kg-1 body weight). Rats maintained on a low protein diet survived for longer, and had significantly less glomerular sclerosis and significantly greater glomerular filtration rates when the experiment ended after 7 months. We conclude that dietary protein influences favourably the development of glomerular scarring and renal failure after subtotal nephrectomy in rats.
我们研究了低蛋白饮食对大鼠肾大部切除术后肾小球硬化和进行性肾衰竭发展的影响。对两组雄性斯普拉格-道利大鼠进行了六分之五肾切除术后研究；第1组维持正常饮食（13.5克/天·千克体重），第2组喂食低蛋白饮食（6克/天·千克体重）。维持低蛋白饮食的大鼠存活时间更长，在7个月后实验结束时，其肾小球硬化明显较少，肾小球滤过率明显更高。我们得出结论，饮食中的蛋白质对大鼠肾大部切除术后肾小球瘢痕形成和肾衰竭的发展有有利影响。
