肾小球硬化症：我们是否更明智了？
Glomerulosclerosis: are we any wiser?
作者信息
el Nahas A M
机构信息
Sheffield Renal Unit, Northern General Hospital, UK.
出版信息
Klin Wochenschr. 1989 Sep 1;67(17):876-81. doi: 10.1007/BF01717343.
Chronic renal failure (CRF) is characterized histologically by progressive glomerulosclerosis (GS) and tubulo-interstitial scarring (TIS). Recently, research has focused on the study of the pathophysiology of GS. Most advances in this field have been derived from the study of various experimental models of CRF and GS in the rat. In this paper, I will review some of the concepts and hypotheses put forward to explain progressive GS and examine their relevance to glomerular scarring and CRF in humans.
慢性肾衰竭（CRF）的组织学特征是进行性肾小球硬化（GS）和肾小管间质纤维化（TIS）。最近，研究集中在GS的病理生理学研究上。该领域的大多数进展都来自对大鼠CRF和GS各种实验模型的研究。在本文中，我将回顾一些为解释进行性GS而提出的概念和假说，并探讨它们与人类肾小球瘢痕形成和CRF的相关性。
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