Tatsuta M, Okuda S, Taniguchi H
Endoscopy. 1983 Jul;15(4):252-6. doi: 10.1055/s-2007-1021525.
The clinicopathological features of minute cancers of the stomach were investigated, and the accuracy of diagnosis of minute cancers by routine endoscopic examinations and by the endoscopic Congo red - methylene blue test were compared. From 1959 to 1979, 56 minute cancer were found in 54 patients. Minute cancers are defined as those of less than 5 mm in the longest diameter. None involved the muscularis propria, but when minute cancers, especially the depressed type, were more than 4 mm in diameter, cancer cells were frequently found to invade the submucosa. Therefore, minute cancers must be diagnosed as early as possible. A correct diagnosis of minute cancers was made in only 25.0% of the cases by routine endoscopic examinations. But with the Congo red--methylene blue test the diagnostic rate was raised significantly to 75.0%. In this test, tumors are seen as areas in which the dyes become bleached to white, in sharp contrast to the unaffected mucosa. This test is more accurate than other methods for diagnosis of minute cancers, because the target area can be biopsied with greater accuracy.
对胃微小癌的临床病理特征进行了研究，并比较了常规内镜检查和内镜刚果红-亚甲蓝试验对微小癌的诊断准确性。1959年至1979年，在54例患者中发现了56例微小癌。微小癌定义为最大直径小于5mm的癌。无一例累及固有肌层，但当微小癌，尤其是凹陷型，直径超过4mm时，常发现癌细胞侵犯黏膜下层。因此，必须尽早诊断微小癌。常规内镜检查仅在25.0%的病例中对微小癌做出了正确诊断。但通过刚果红-亚甲蓝试验，诊断率显著提高到75.0%。在该试验中，肿瘤表现为染料变为白色的区域，与未受影响的黏膜形成鲜明对比。该试验比其他微小癌诊断方法更准确，因为可以更准确地对目标区域进行活检。
