Tatsuta M, Okuda S, Taniguchi H, Tamura H
Endoscopy. 1979 Sep;11(3):166-71. doi: 10.1055/s-0028-1098345.
The distribution of intestinal metaplasia in relation to the acid-secreting are was investigated in 66 patients not suffering from gastroduodenal diseases. Studies were made via the endoscopic Congo Red test in combination with the methylene blue staining method. In this test, the acid-secreting area is identified as a "discolored" area in which Congo Red turns from red to blue-black, and areas of intestinal metaplasia were observed as areas staining blue with methylen blue. A close relationship was found between the acid-secreting area and the distribution of intestinal metaplasia; in general, intestinal metaplasia tended to be more extensive and more frequent when the acid-secreting area was small. It was also found that intestinal metaplasia increased with age. However, even in patients who were over 40 years of age, intestinal metaplasia was seen in 12.5% only, if the acid-secreting area was large. Hence, it appears likely that development of intestinal metaplasia is more closely related to the acid-secreting function than to aging.
对66例未患胃十二指肠疾病的患者，研究了肠化生与泌酸区域的关系。研究通过内镜刚果红试验结合亚甲蓝染色法进行。在该试验中，泌酸区域被识别为“褪色”区域，刚果红在其中由红色变为蓝黑色，肠化生区域则被观察为用亚甲蓝染成蓝色的区域。发现泌酸区域与肠化生分布之间存在密切关系；一般来说，当泌酸区域较小时，肠化生往往更广泛、更频繁。还发现肠化生随年龄增加。然而，即使在40岁以上的患者中，如果泌酸区域较大，肠化生仅见于12.5%的患者。因此，肠化生的发展似乎与泌酸功能的关系比与衰老的关系更为密切。
