Tanaka A, Machida T, Miki M, Shimada T
Eur J Nucl Med. 1983;8(7):317-20. doi: 10.1007/BF00253759.
99mTc-Dimercaptopropionic acid (DMP), a new renal scanning agent was synthesized, and the optimum preparative conditions and stability of this compound were determined. It was demonstrated that scans performed with this agent in rats showed highly selective renal images which may be of promise in future clinical use. The relationships between chemical structure and renal affinity are discussed based on the present results.
合成了一种新型肾扫描剂99m锝-二巯基丙酸(DMP),并确定了该化合物的最佳制备条件和稳定性。结果表明,用该制剂对大鼠进行扫描可显示出高度选择性的肾脏图像,有望在未来临床应用中发挥作用。根据目前的结果讨论了化学结构与肾脏亲和力之间的关系。