Kitrou M P, Phytou-Pallikari A, Tzannes S E, Virvidakis K, Mountokalakis T D
Eur J Respir Dis. 1983 Jul;64(5):347-54.
Serum calcium was prospectively studied in 50 consecutive patients with active pulmonary tuberculosis. Twenty-four of them (48%) developed hypercalcaemia during an observation period of at least 8 weeks. Maximal increase in serum calcium (corrected for serum albumin) occurred three weeks after initiation of treatment, by which time 28% of the patients were hypercalcaemic. The increase in serum calcium was followed by a spontaneous remission. Only two patients developed symptoms related to hypercalcaemia, which promptly responded to steroid administration. No patient received vitamin D supplements before or during the study. No correlation could be found between hypercalcaemia and either the presence of acid-fast bacilli in the sputum or the season of the year. There was a trend for higher serum calcium values in the patients with the more severe radiographic changes on admission. Hypercalcaemia in patients with pulmonary tuberculosis seems to be triggered by chemotherapy. However, the mechanism(s) by which anti-tuberculosis treatment affects calcium metabolism remains uncertain.
对50例连续性活动型肺结核患者的血清钙进行了前瞻性研究。其中24例（48%）在至少8周的观察期内出现高钙血症。血清钙（校正血清白蛋白后）的最大升高发生在治疗开始后3周，此时28%的患者出现高钙血症。血清钙升高后出现自发缓解。只有2例患者出现与高钙血症相关的症状，使用类固醇治疗后症状迅速缓解。在研究前或研究期间，没有患者接受维生素D补充剂。高钙血症与痰中抗酸杆菌的存在或一年中的季节均无相关性。入院时影像学改变越严重的患者，其血清钙值有升高趋势。肺结核患者的高钙血症似乎由化疗引发。然而，抗结核治疗影响钙代谢的机制仍不确定。
