Chan T Y, Chan C H, Shek C C
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
Singapore Med J. 1994 Dec;35(6):613-5.
We studied the prevalence of hypercalcaemia in 34 Chinese patients with pulmonary (n = 32) or miliary (n = 2) tuberculosis. None of these subjects were given vitamin D or calcium supplements. Plasma calcium levels were measured at presentation and at 1- to 2-monthly intervals after treatment. During the 6-month study period, two patients (6%) developed hypercalcaemia (plasma calcium greater than 2.51 mmol/l), as compared to figures of 16% to 28% in the United States and India. By correcting the plasma calcium to a normal albumin, five (15%) of our patients were hypercalcaemic, as compared to a figure of 48% in Greece. Apart from variations in methodology, discrepancies in the reported prevalence of hypercalcaemia in tuberculosis may be due to differences in sun exposure, and vitamin D and calcium intake.
我们研究了34例中国肺结核（n = 32）或粟粒性结核（n = 2）患者高钙血症的患病率。这些受试者均未补充维生素D或钙。在就诊时以及治疗后每隔1至2个月测量血浆钙水平。在为期6个月的研究期间，有2例患者（6%）出现高钙血症（血浆钙大于2.51 mmol/L），而美国和印度的这一比例为16%至28%。通过将血浆钙校正至正常白蛋白水平，我们有5例患者（15%）出现高钙血症，而希腊的这一比例为48%。除了方法学上的差异外，结核病中报道的高钙血症患病率存在差异可能是由于日照、维生素D和钙摄入量的不同。
