Martonen T B, Clark M L
Fundam Appl Toxicol. 1983 Jan-Feb;3(1):10-5. doi: 10.1016/s0272-0590(83)80166-3.
The hygroscopic growth of phosphoric acid aerosol (Dc greater than 0.5 micron) within the human tracheobronchial tree is modeled to investigate changes in deposition characteristics when compared to nonhygroscopic aerosols of identical preinspired size. Phosphoric acid particles are assumed to grow in a stepwise fashion to 99% relative humidity (RH) within conducting airways of the lung, having initially reached equilibrium at 90% RH (T = 37 degrees C) in the trachea. Deposition efficiencies for growth and no growth are calculated from theoretical equations for inertial impaction, sedimentation and diffusion. The results show that neglecting the growth of an inhaled phosphoric acid aerosol may result in underestimation of the total deliverable dose by a factor of as much as 600-700%. Significant differences in regional deposition sites for hygroscopic or nonhygroscopic aerosols are predicted. Increased deposition efficiencies imply that measured physical properties (respirable fraction, aerodynamic diameter) of aerosols alone are not sufficient to assess deposition characteristics within the lung; hygroscopic growth must also be considered.
对人气管支气管树内磷酸气溶胶（空气动力学直径大于0.5微米）的吸湿增长进行建模，以研究与相同吸气前尺寸的非吸湿气溶胶相比时沉积特性的变化。假设磷酸颗粒在肺的传导气道内以逐步方式增长至相对湿度（RH）99%，最初在气管中于90%相对湿度（T = 37摄氏度）达到平衡。根据惯性撞击、沉降和扩散的理论方程计算增长和不增长情况下的沉积效率。结果表明，忽略吸入的磷酸气溶胶的增长可能导致可输送总剂量的低估高达600 - 700倍。预测了吸湿性或非吸湿性气溶胶在区域沉积部位的显著差异。沉积效率的增加意味着仅测量气溶胶的物理特性（可吸入分数、空气动力学直径）不足以评估肺内的沉积特性；还必须考虑吸湿增长。
