Liu L H, Ni C
Graefes Arch Clin Exp Ophthalmol. 1983;220(4):179-83. doi: 10.1007/BF02186665.
We studied the morphology of metastatic tumors in three rabbits with implanted choroidal Greene melanoma. The tumor-bearing eyes were perforated and destroyed by the expanding tumors 10 to 12 weeks after implantation. The animals then lost body weight and became cachectic; they were suspected of having metastases and were sacrificed. The interval between the destruction of the eye and the discovery of metastases was 1 to 14 weeks. Widespread metastases involved the liver, lungs, kidneys, and subcutaneous tissue, with the greatest number of tumors in the liver and lungs. Histopathologic findings in the metastases and primary tumors were identical. This model may be considered appropriate for study of human uveal melanoma because (1) the biological behavior is similar to that of human uveal melanoma, (2) the primary and metastatic tumors are histologically similar, and (3) the large size of the rabbit's eye facilitates observation and manipulation.
我们研究了三只植入脉络膜格林氏黑色素瘤的兔子体内转移性肿瘤的形态。植入后10至12周，荷瘤眼被不断生长的肿瘤穿孔并破坏。随后，这些动物体重减轻并出现恶病质；怀疑它们发生了转移，遂将其处死。从眼被破坏到发现转移的间隔时间为1至14周。广泛转移累及肝脏、肺、肾和皮下组织，其中肝脏和肺中的肿瘤数量最多。转移瘤和原发肿瘤的组织病理学表现相同。该模型可被认为适合用于研究人类葡萄膜黑色素瘤，因为（1）其生物学行为与人类葡萄膜黑色素瘤相似，（2）原发肿瘤和转移瘤在组织学上相似，（3）兔子眼睛较大便于观察和操作。
