Ishida H, Isurugi K, Niijima T, Matsumoto K, Nomura K, Hirose K
Int J Androl. 1983 Jun;6(3):229-34. doi: 10.1111/j.1365-2605.1983.tb00536.x.
A 25-year-old man was first seen complaining of impotence and found to have a pituitary tumour and hyperprolactinaemia. Both testes were small and atrophic, but a testicular tumour was not apparent. Biopsy of the right testis was performed, and the pathology report described thickening of the seminiferous tubule walls and impaired spermatogenesis. The patient refused to undergo an operation for his pituitary tumour and was lost to follow-up. 5 years later, the same patient presented with enlargement of his right testis, and this and the pituitary tumour were excised. The testicular tumour was classified as seminoma, and the pituitary tumour as an adenoma with low malignancy. Re-examination of the previous specimen of his right testis revealed foci of carcinoma-in-situ. This is an additional example of the growth of an invasive germ cell tumour from non-invasive carcinoma-in-situ of the testis.
一名25岁男性因阳痿首次就诊，被发现患有垂体瘤和高泌乳素血症。双侧睾丸均小且萎缩，但未发现睾丸肿瘤。对右侧睾丸进行了活检，病理报告显示生精小管壁增厚且精子发生受损。患者拒绝接受垂体瘤手术，随后失访。5年后，该患者右侧睾丸肿大，遂将睾丸及垂体瘤切除。睾丸肿瘤被分类为精原细胞瘤，垂体瘤为低恶性腺瘤。重新检查其右侧睾丸之前的标本发现原位癌灶。这是睾丸非侵袭性原位癌发展为侵袭性生殖细胞肿瘤的又一实例。
