Liotti F S, Bodo M, Talesa V
J Cancer Res Clin Oncol. 1983;106(1):69-70. doi: 10.1007/BF00399900.
In a preceding report evidence has been presented that ascorbic acid (AA) accelerated solid tumor growth obtained by inoculating tumor ascites cells into the subcutaneous dorsal region of inbred Balb/cf/Had/Se substrain mice. The present work investigates whether this effect is the result of a direct action of AA on neoplastic cell multiplication or of an indirect action on the tumor cells mediated by changes induced by AA in the organism bearing the tumor. The results obtained demonstrate that AA at low doses (microgram 10-30/ml) stimulates ascites tumor cell multiplication in vitro, while at high doses (microgram 60-120/ml) the opposite occurs. These results suggest that the major growth of solid tumors observed in mice treated with AA may be attribute to the capacity of this substance to favor the multiplication of ATP cells which were used to induce the tumors.
在之前的一份报告中，已有证据表明，将肿瘤腹水细胞接种到近交系Balb/cf/Had/Se亚系小鼠的背部皮下区域所形成的实体瘤，其生长会被抗坏血酸（AA）加速。目前的研究工作旨在探究这种效应是AA对肿瘤细胞增殖的直接作用所致，还是通过AA在荷瘤机体中诱导的变化介导而对肿瘤细胞产生的间接作用。所获得的结果表明，低剂量（10 - 30微克/毫升）的AA在体外可刺激腹水肿瘤细胞增殖，而高剂量（60 - 120微克/毫升）时则出现相反情况。这些结果提示，在用AA处理的小鼠中观察到的实体瘤主要生长，可能归因于该物质促进用于诱导肿瘤的ATP细胞增殖的能力。
