Hay R J, Calderon R A, Collins M J
J Invest Dermatol. 1983 Sep;81(3):270-4. doi: 10.1111/1523-1747.ep12518292.
We have established a reproducible mouse model of dermatophytosis using Trichophyton quinckeanum. There was considerable variation in the pathogenic potential among 10 different strains of T. mentagrophytes or T. quinckeanum; susceptibility to the infection varied with the inbred strain of mouse used, with BALB/c or BALB/K mice proving to be the most susceptible. The primary infection was characterized by the development of a scutulum or crust consisting of large quantities of dermatophyte mycelium, dense infiltration with neutrophils, but minimal epidermal proliferation. By contrast, a secondary infection initiated 30 days after the primary infection showed different features with early and almost total elimination of fungal elements, a predominantly mononuclear cell response, and epidermal proliferation. If the secondary infection was given at the peak of the primary illness (day 7), there was a mononuclear cell response with epidermal proliferation but fungal mycelium was prominent and not quickly eliminated. The value of this model in investigating the kinetics of the immune response to experimental dermatophytosis is discussed.
我们使用须发癣菌建立了一种可重复的皮肤癣菌病小鼠模型。在10种不同的须癣毛癣菌或须发癣菌菌株中，致病潜力存在相当大的差异；对感染的易感性因所用小鼠的近交系而异，结果表明BALB/c或BALB/K小鼠最易感。原发性感染的特征是形成由大量皮肤癣菌菌丝体组成的角质层或痂皮，有大量中性粒细胞浸润，但表皮增殖极少。相比之下，原发性感染30天后引发的继发性感染表现出不同的特征，真菌成分早期几乎完全清除，主要是单核细胞反应，以及表皮增殖。如果在原发性疾病的高峰期（第7天）进行继发性感染，则会出现单核细胞反应并伴有表皮增殖，但真菌菌丝体突出且不会迅速清除。本文讨论了该模型在研究实验性皮肤癣菌病免疫反应动力学方面的价值。
