Duffy S W, Roberts M M, Elton R A
J Epidemiol Community Health. 1983 Jun;37(2):127-31. doi: 10.1136/jech.37.2.127.
In a study of risk factors for breast cancer in women aged between 40 and 60 information was obtained from 236 cases identified at a diagnostic clinic and 2962 controls with no breast abnormality who attended a screening clinic. Statistical analysis of the data used information on a further 167 women who had attended both clinics to correct for possible between clinic bias in questionnaire responses. Relative risk was estimated in four 5 year age groups, and a significant excess risk was found for women under 55 who had undergone previous breast biopsy and for women aged 50-55 who were premenopausal or who had a family history of breast cancer. No significant risk was found to be associated with marital status, age at first pregnancy, breast feeding, or use of hormonal drugs. It is concluded that epidemiological information is of little value in identifying high risk groups for a screening programme in this age range.
在一项针对40至60岁女性乳腺癌风险因素的研究中，从一家诊断诊所确诊的236例病例以及一家筛查诊所的2962名无乳腺异常的对照者那里获取了信息。对数据的统计分析利用了另外167名同时去过两家诊所的女性的信息，以校正问卷回答中可能存在的诊所间偏差。在四个5岁年龄组中估计了相对风险，发现55岁以下曾接受过乳腺活检的女性以及50至55岁绝经前或有乳腺癌家族史的女性存在显著的额外风险。未发现婚姻状况、初孕年龄、母乳喂养或使用激素药物与显著风险相关。得出的结论是，在确定该年龄范围内筛查项目的高危人群方面，流行病学信息价值不大。
