Arp E W, Wolf P H, Checkoway H
J Occup Med. 1983 Aug;25(8):598-602.
Previous epidemiological studies on one cohort of rubber industry workers indicated that observed mortality excesses from lymphocytic leukemia were related to solvent exposures. The results of a detailed examination of the solvent exposure histories of 15 cases of lymphocytic leukemia from this cohort and 30 matched industry controls are presented. Extensive review of historical solvent use, raw materials specifications and job description records were used to reconstruct exposures to specific agents. Cases were 4.5 times as likely as controls to have had direct exposures to both benzene and other solvents. Analysis by manufacturing production source of solvent revealed that cases spent greater proportions of their work experience in jobs with potential exposures to coal tar-based benzene and xylene. No differences were seen for petroleum-derived solvents.
先前针对一组橡胶行业工人的流行病学研究表明，观察到的淋巴细胞白血病死亡率过高与接触溶剂有关。本文呈现了对该队列中15例淋巴细胞白血病病例和30例匹配的行业对照的溶剂接触史进行详细检查的结果。通过广泛查阅历史溶剂使用情况、原材料规格和工作描述记录来重建对特定制剂的接触情况。病例直接接触苯和其他溶剂的可能性是对照的4.5倍。按溶剂的制造生产来源进行分析发现，病例在有可能接触煤焦油基苯和二甲苯的工作岗位上度过的工作经历比例更高。而对于石油衍生溶剂，未发现差异。
