Harpey J P, Charpentier C, Goodman S I, Darbois Y, Lefèbvre G, Sebbah J
J Pediatr. 1983 Sep;103(3):394-8. doi: 10.1016/s0022-3476(83)80410-7.
Seven infants in one kindred died: one was stillborn; the others, who were floppy at birth and were breast-fed, developed a disorder with the odor of sweaty feet and died in early infancy. In two further pregnancies, 3-hydroxvisovaleric, glutaric, and C6-C10-dicarboxylic acids were demonstrated in the mother's urine during the seventh month. Riboflavin therapy in the last trimester of pregnancy and a riboflavin-rich diet given the infants prevented this syndrome. The presence of abnormal erythrocyte glutathione-reductase activity in the mother while she excreted normal amounts of riboflavin in her urine indicates a probable disorder of riboflavin metabolism resulting in multiple acyl-CoA dehydrogenase deficiency.
一名为死产；其他婴儿出生时软弱无力，以母乳喂养，出现了有汗脚气味的病症，并在婴儿早期死亡。在另外两次妊娠中，妊娠第七个月时在母亲尿液中检测到了3-羟基戊二酸、戊二酸和C6-C10二羧酸。在妊娠晚期进行核黄素治疗并给予婴儿富含核黄素的饮食可预防此综合征。母亲尿液中核黄素排泄量正常，但红细胞谷胱甘肽还原酶活性异常，这表明可能存在核黄素代谢紊乱，导致多种酰基辅酶A脱氢酶缺乏。
