Russell I J, Papaioannou C, McDuffie F C, MacIntyre S, Kushner I
J Rheumatol. 1983 Jun;10(3):425-33.
Complement activity in normal human serum was rapidly depleted by the addition of monosodium urate crystals (MSUC), while the same MSUC preparation had little effect on complement activity in 4 of 8 sera from patients with common variable immunodeficiency (CVID). The degree of complement depletion in the CVID sera correlated with their C-reactive protein (CRP) concentrations but not with their concentrations of IgG. MSUC-induced complement depletion in the 4 poorly reactive sera was partially restored by addition of CRP or by normalizing the IgG concentration, but not by addition of IgM or IgA. It is proposed that CRP, an acute phase protein, may play a role in the pathogenesis of gouty arthritis attacks occurring in some patients following surgery or acute physical illness.
添加尿酸钠晶体（MSUC）后，正常人血清中的补体活性迅速耗尽，而相同的MSUC制剂对8例常见可变免疫缺陷（CVID）患者血清中的4例补体活性影响很小。CVID血清中的补体消耗程度与其C反应蛋白（CRP）浓度相关，但与其IgG浓度无关。通过添加CRP或使IgG浓度正常化，可部分恢复4例反应性较差血清中MSUC诱导的补体消耗，但添加IgM或IgA则不能。有人提出，急性期蛋白CRP可能在一些患者术后或急性身体疾病后发生的痛风性关节炎发作的发病机制中起作用。
